Celeste Allaband

Celeste Allaband

Veterinarian (DVM) and Microbiome Researcher (PhD). Currently a postdoctoral researcher in Rob Knight's laboratory at UC San Diego.

Publications

Clearing the plate: a strategic approach to mitigate well-to-well contamination in large-scale microbiome studies.

Published in Msystems, 2024

Using barcoded Matrix Tubes, we show a significant reduction in cross-contamination compared to conventional plate-based approaches; this innovation improves large-scale study design by shortening processing times, simplifying analysis, facilitating metadata curation, and producing more reliable results.

Recommended citation: Brennan, et al. (2024). "Clearing the plate: a strategic approach to mitigate well-to-well contamination in large-scale microbiome studies.." Msystems, 9(10):e00985-24. https://doi.org/10.1128/msystems.00985-24

The changing metabolic landscape of bile acids – keys to metabolism and immune regulation.

Published in Nature reviews Gastroenterology & hepatology, 2024

Existing bile acids, both host and microbial-derived, have been shown to serve as agonists for multiple transcription factors and receptors, which is discussed extensively in this Perspective.

Recommended citation: Mohanty, et al. (2024). "The changing metabolic landscape of bile acids–keys to metabolism and immune regulation.." Nature reviews Gastroenterology & hepatology. Jul;21(7):493-516. https://doi.org/10.1038/s41575-024-00914-3

Impact of diet change on the gut microbiome of common marmosets (Callithrix jacchus).

Published in Journal of Applied Microbiology, 2024

Our study shows that a gel diet compared to a biscuit diet improves the health of a marmoset colony, is linked to increases in Bifidobacterium species, and increases the removal of molecules associated with disease.

Recommended citation: Tang-Wing, et al. (2024). "Impact of diet change on the gut microbiome of common marmosets (Callithrix jacchus).." Msystems, Aug 20;9(8):e00108-24. https://doi.org/10.1128/msystems.00108-24

Evaluation of the safety and efficacy of fecal microbiota transplantations in bottlenose dolphins (Tursiops truncatus) using metagenomic sequencing.

Published in Journal of Applied Microbiology, 2024

Fecal microbiota transplantation holds promise in dolphin medicine as a therapeutic tool to restore healthy gut microbiota without antibiotic use.

Recommended citation: Linnehan, et al. (2024). "Evaluation of the safety and efficacy of fecal microbiota transplantations in bottlenose dolphins (Tursiops truncatus) using metagenomic sequencing.." Journal of Applied Microbiology, Volume 135, Issue 2, February 2024, lxae026. https://doi.org/10.1093/jambio/lxae026

Compositionally aware phylogenetic beta-diversity measures better resolve microbiomes associated with phenotype.

Published in Msystems, 2022

We show using simulated and real data that our new methods provide improved classification accuracy of ordinal sample clusters and increased effect size between sample groups on beta-diversity distances.

Recommended citation: Martino, et al. (2022). "Compositionally aware phylogenetic beta-diversity measures better resolve microbiomes associated with phenotype.." Msystems, 7(3):e00050-22. https://doi.org/10.1128/msystems.00050-22

Intermittent hypoxia and hypercapnia alter diurnal rhythms of luminal gut microbiome and metabolome.

Published in Msystems, 2021

We found changes in microbial families and metabolites during different parts of the day that regulate many metabolic pathways contributing to the increased risk for heart disease seen in patients with obstructive sleep apnea.

Recommended citation: Allaband, et al. (2021). "Intermittent hypoxia and hypercapnia alter diurnal rhythms of luminal gut microbiome and metabolome.." Msystems, 6(3):10-128. https://doi.org/10.1128/msystems.00116-21

How the gut microbiome affects distal organs.

Published in Hills Global Symposium 2024, 2020

These proceedings discuss how the microbiome can affect additional organs in the host body.

Recommended citation: Allaband and Knight. (2024). "How the gut microbiome affects distal organs.." Hills Global Symposium.

Wildlife-microbiome interactions and disease: exploring opportunities for disease mitigation across ecological scales.

Published in Drug Discovery Today: Disease Models, 2018

In this perspective, we examine how the microbiome influences gastrointestinal disorders, metabolic dysregulation, reproduction, and disease susceptibility in captive wildlife. Investigation of wildlife, and specifically captive wildlife, affords a unique opportunity to gain understanding of the broad diversity of the associated microbiota and learn from nature’s molecular and microbial responses to disease.

Recommended citation: Williams, et al. (2024). "Wildlife-microbiome interactions and disease: exploring opportunities for disease mitigation across ecological scales.." Drug Discovery Today: Disease Models. 2018 Jun 1;28:105-15. https://doi.org/10.1016/j.ddmod.2019.08.012